Originally Posted by Ramskull
I have an 03 qc 2500 with a 5.7. She has 193,000 and is ready for a change. I have been looking at the 6.4 392 520hp but a friend of mine mentioned the V10. Are there any mods that have to be done for the swap or will all bolt up (motor, tranny). going to make a change soon, so if you guys have any good info please let me know.
Definitely different transmission and most likely driveshaft. Different computers and wiring. The 03 2500 is the only year 3rd gen body/chassis (02 2500 was still a 2nd gen body/chassis) to have the V10. It will physically bolt in, but you would need a donor truck to make it all work right. If you want a challenge, go for it. If not, rebuild (stock or go for more power/stroke) or replace your engine and keep on truckin'.