If you're going lift and big tires, AWD isnt that big a deal,
just use 4Hi Lock for Winter or OffRoad and you're good to go Bud.
I use AWD (4-auto) for racing
so its only in 4wd for launch then releases to 2wd for the rest of the run
a Reg Cab 4x4 is going to suck on fuel with lift and 35's though
You will need a re-gear to help with that,(4.56's)
I cant really comment on fuel economy, I don't do any highway miles
and bag the shyte out of it in the city on 94 octane
I barely get 400km per tank lol, avg 12mpg city if I'm lucky
Here's an old pic of my dropped 4x4 RCSB on 32's
next to a dealers lifted 4x4 RCSB on 35's to give you an idea...
Hope this helps your decision