Best advice: Don't crash
My tips are:
Keep stock pressure in the front tires, lower the pressure a bit in the rear, lowest on stock tires should be 26psi.
Tail gate up or down has never made a difference for me with the quad cab but some of the regular cab guys swear by it.
Tow/haul worked on the 3rd gens but I haven't found it does as much in the 4th gens except hold the shift longer which isn't a bad thing.
Don't load up the converter, the traction control is a bitch in these trucks now and will pull loads of timing, just leave from a dead pedal.
Also, realistically expect mid 15s with a QC 4wd, anything less and you can be happy.