Here are some real world results of a Predator install on my 2007 Ram MegaCab with the HEMI.
Check out the dyno sheets and the narrative. I have the Predator on two HEMI powered vehicles. I have gotten real gains out of the canned 91 octane tune on my truck, a similar gain with that tune on my 300 SRT8 and when I did the CMR tune to the car, OMFG!!!!!
So I say YES!!!