I race against Cummins Rams that run in 4WD Hi range. Thats the only way they can hook with street tires. In the eighth mile we're typically running at mid 70's mph, quarter mile, just under 100. As long as you're going in a straight line, 4WD is ok, if you turn, it can actually be dangerous. Sometimes driving in snow, my truck will kick the rear end sideways in 4WD. If you drag race in 4WD, you can possibly stretch the drive chain in the transfer case. I use my truck to skid out heavy logs in 4LO and have had to replace the chain. It's pretty easy to replace. I skid logs with 2-3,000 lbs in the bed and it will pull hard enough to break 15,000 lb dacron tow rope.